Iminat C - Primaxin (imipenem/cilastatin)

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Price:	$33.00
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SKU:	IMCT123456
Manufacturer:	Natco Pharma
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ImiNat C (imipenem and cilastatin) by natco is generic version of Primaxin I.M. Primaxin IV.It comes in 500 mg injection form .

Generic Primaxin

What is Iminat C (imipenem and cilastatin)?

Imipenem is an antibiotic that fights serious infections caused by bacteria.

Cilastatin helps imipenem work more effectively by preventing the breakdown of the antibiotic in the kidneys.

ImiNat C (imipenem and cilastatin) is used to treat severe infections of the lower respiratory tract, skin, stomach, female reproductive organs, and other body systems.

ImiNat C (imipenem and cilastatin) may also be used for purposes other than those listed here.

What is the most important information I should know about ImiNat C (imipenem and cilastatin)?

Do not use this medication if you are allergic to ImiNat C (imipenem and cilastatin), or to lidocaine or other local anesthetics (numbing medicine). You should not use ImiNat C (imipenem and cilastatin) if you have heart block.

Before using ImiNat C (imipenem and cilastatin), tell your doctor if you have kidney disease (or if you are on dialysis), or a seizure disorder.

Also tell your doctor if you are either allergic to or are currently taking a penicillin or cephalosporin antibiotic such as Amoxil, Augmentin, Bactocill, Beepen-VK, Ceclor, Ceftin, Duricef, Dycill, Dynapen, Keflex, Ledercillin VK, Omnipen, Pen-V, Pfizerpen, Principen, Veetids, and others.

Before using ImiNat C (imipenem and cilastatin), tell your doctor if you are also taking ganciclovir (Cytovene) or probenecid (Benemid).

Primaxin IM (for the muscle) and Primaxin IV (for the vein) are different forms of this medicine and should be used only for their specific type of injection. Do not inject Primaxin IM into a vein and do not inject Primaxin IV into a muscle.

Call your doctor at once if you have serious side effects such as pounding heartbeats, confusion, hallucinations, seizure (convulsions), feeling light-headed, fainting, flu symptoms, nausea, stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes), or a severe blistering, peeling, and red skin rash.

Less serious side effects may include pain, swelling, or redness where the medicine was injected, mild stomach discomfort, sore throat, vaginal itching or discharge, mild skin rash, dizziness or tired feeling, numbness or tingling, or ringing in your ears.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

What should I discuss with my healthcare provider before use ImiNat C (imipenem and cilastatin)?

Before using ImiNat C (imipenem and cilastatin), tell your doctor if you have:

kidney disease (or if you are on dialysis);
epilepsy or other seizure disorder;
a history of allergy to penicillin antibiotics such as Amoxil, Augmentin, Omnipen, Principen, Dycill, Dynapen, Bactocill, Beepen-VK, Ledercillin VK, Pen-V, Pfizerpen, Veetids, and others; or
a history of allergy to cephalosporin antibiotics such as Ceclor, Ceftin, Duricef, Keflex, and others.

If you have any of these conditions, you may not be able to use ImiNat C (imipenem and cilastatin), or you may need a dose adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether ImiNat C (imipenem and cilastatin) passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use ImiNat C (imipenem and cilastatin)?

ImiNat C (imipenem and cilastatin) is given as an injection through a needle placed into a vein (IV) or into a muscle (IM).

ImiNat C (imipenem and cilastatin) is usually given in a clinic or hospital setting. The IV medicine must be given as a slow infusion and can take up to an hour to complete. Tell your caregiver if you feel nauseated during the infusion. You may need to receive the medicine at a slower rate.

The IM form of ImiNat C (imipenem and cilastatin) is given as a rapid injection into a muscle. You may be given instructions on how to inject your medicine at home. Do not use this medicine at home if you do not fully understand how to give the injection and properly dispose of needles and other items used in giving the medicine.

ImiNat C (imipenem and cilastatin) is usually given as long as needed until your infection has cleared or you have been symptom-free for at least 48 hours.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated.ImiNat C ImiNat C (imipenem and cilastatin) will not treat a viral infection such as the common cold or flu.

Do not give this medication to another person, even if they have the same symptoms you do.

ImiNat C (imipenem and cilastatin) is a powder that must be mixed with a liquid (diluent). Primaxin IM and Primaxin IV are each mixed with different types of diluent.

Do not mix Primaxin IM or draw your dose into a syringe until you are ready to inject the medicine.

After mixing Primaxin IV, you may keep it in a refrigerator and use it within 24 hours. You may also store the mixed IV medicine at room temperature if you use it within 4 hours. Store unmixed ImiNat C (imipenem and cilastatin) powder at room temperature away from moisture and heat.

What happens if I miss a dose?

If ImiNat C (imipenem and cilastatin) is given in a hospital setting, it is not likely that you will miss a dose. If you are using the medication at home and you miss a dose, give the injection as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at your next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of an ImiNat C (imipenem and cilastatin) overdose may include weakness, drooping eyelid, tremors, trouble breathing, or seizure (black-out or convulsions).

What should I avoid while using ImiNat C (imipenem and cilastatin)?

ImiNat C (imipenem and cilastatin) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

fast or pounding heartbeats;
diarrhea that is watery or bloody;
confusion, tremors, hallucinations, seizure (convulsions);
feeling light-headed, fainting;
fever, chills, body aches, flu symptoms;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious side effects may be more likely to occur, such as:

pain, swelling, or redness where the medicine was injected;
mild nausea, vomiting, heartburn, or stomach pain;
sore throat;
vaginal itching or discharge;
mild skin rash or itching;
dizziness or tired feeling;
numbness or tingling; or
ringing in your ears.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

ImiNat C (imipenem and cilastatin) Dosing Information

Usual Adult Dose for Aspiration Pneumonia:

250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: Parenteral therapy should be continued until the patient's clinical condition stabilizes and fever subsides. Oral antibiotic therapy may then be initiated according to microbiologic sensitivity data. Therapy of documented anaerobic pleuropulmonary infections should be continued until the infiltrate is cleared or a residual scar forms, sometimes requiring 2 to 4 months.

Usual Adult Dose for Bacteremia:

500 mg IV every 6 hours or 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Septicemia:

500 mg IV every 6 hours or 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Bronchitis:

Intravenous: 250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Intramuscular:

Mild to moderate infections: 500 to 750 mg IM every 12 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 1500 mg/day

Usual Adult Dose for Pelvic Infections:

Intravenous: 250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Intramuscular:

Mild to moderate infections: 500 to 750 mg IM every 12 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 1500 mg/day

Usual Adult Dose for Endometritis:

Intravenous: 250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Intramuscular:

Mild to moderate infections: 500 to 750 mg IM every 12 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 1500 mg/day

Usual Adult Dose for Deep Neck Infection:

250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 3 to 4 weeks, depending on the nature and severity of the infection

Usual Adult Dose for Endocarditis:

250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Febrile Neutropenia:

500 mg IV every 6 hours if suspected causative organism is fully susceptible, 1 g IV every 8 hours if other suspected causative organisms are moderately susceptible, or 1 g IV every 6 hours if Pseudomonas aeruginosa is suspected causative organism (based on imipenem content)

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: Once the patient is stable and afebrile for at least 24 hours, and the absolute neutrophil count is at least 500 cells/mm3, oral antimicrobial therapy, based on susceptibility patterns, may be initiated. Then duration of therapy is dependent on the clinical situation.

Usual Adult Dose for Intraabdominal Infection:

Intravenous:

250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 7 to 14 days, depending on the nature and severity of the infection

Intramuscular:

Mild to moderate infections: 750 mg IM every 12 hours

Maximum dose: 1500 mg/day

Usual Adult Dose for Joint Infection:

250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 3 to 4 weeks, depending on the nature and severity of the infection

Longer therapy, 6 weeks or more, may be required for prosthetic joint infections.

Usual Adult Dose for Meningitis:

250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 14 days, depending on the nature and severity of the infection

Treatment of meningitis due to Listeria species should be continued for 3 to 6 weeks.

Usual Adult Dose for Nosocomial Pneumonia:

250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Initial empiric treatment with broad-spectrum coverage according to the hospital's and/or ICU's antibiogram is recommended if multidrug-resistant organisms are suspected.

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: If the causative organism is not Pseudomonas aeruginosa, the duration of treatment should be as short as clinically possible (e.g., as little as 7 days) to reduce the risk of superinfections with resistant organisms.

Usual Adult Dose for Osteomyelitis:

250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 4 to 6 weeks, depending on the nature and severity of the infection

Chronic osteomyelitis may require additional oral antimicrobial therapy, possibly for up to 6 months. Surgical debridement of devitalized bone is also critical.

Usual Adult Dose for Peritonitis:

250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 10 to 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Pneumonia:

Intravenous: 250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 7 days if pneumococcal pneumonia is suspected and up to 21 days for other infecting organisms, depending on the nature and severity of the infection

Intramuscular:

Mild to moderate infections: 500 to 750 mg IM every 12 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 1500 mg/day

Usual Adult Dose for Pyelonephritis:

250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Skin or Soft Tissue Infection:

Intravenous: 250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 7 to 10 days, or for 3 days after acute inflammation resolves, depending on the nature and severity of the infection

For more severe infections, such as diabetic soft tissue infections, 14 to 21 days of therapy may be required.

Intramuscular:

Mild to moderate infections: 500 to 750 mg IM every 12 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 1500 mg/day

Usual Adult Dose for Skin and Structure Infection:

Intravenous: 250 mg IV every 6 hours or 500 mg to 1 g IV every 6 to 8 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 7 to 10 days, or for 3 days after acute inflammation resolves, depending on the nature and severity of the infection

For more severe infections, such as diabetic soft tissue infections, 14 to 21 days of therapy may be required.

Intramuscular:

Mild to moderate infections: 500 to 750 mg IM every 12 hours (based on imipenem content), depending on the nature and severity of the infection

Maximum dose: 1500 mg/day

Usual Adult Dose for Urinary Tract Infection:

Uncomplicated: 250 mg IV every 6 hours (based on imipenem content)

Complicated: 500 mg IV every 6 hours (based on imipenem content)

Maximum dose: 50 mg/kg/day or 4 g/day, whichever is less

Duration: 3 to 7 days, depending on the nature and severity of the infection

Usual Pediatric Dose for Bacteremia:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Endocarditis:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Intraabdominal Infection:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Joint Infection:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Osteomyelitis:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Peritonitis:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Pneumonia:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Pyelonephritis:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Septicemia:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Bacterial Infection:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Urinary Tract Infection:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Skin and Structure Infection:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Bronchitis:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Pelvic Infections:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Endometritis:

Non-CNS infections: (based on imipenem content)

0 to 4 weeks, 1199 g or less: 20 to 25 mg/kg IV every 12 to 24 hours

7 days or less, 1200 to 1500 g: 20 to 25 mg/kg IV every 12 hours

7 days or less, 1501 g or more: 25 mg/kg IV every 12 hours

8 days up to 4 weeks, 1200 to 1500 g: 20 to 25 mg/kg IV every 8 to 12 hours

8 days up to 4 weeks, 1501 g or more: 25 mg/kg IV every 8 hours

4 weeks or older: 15 to 25 mg/kg IV every 6 hours

Maximum dose: 2 g/day for fully susceptible organisms and 4 g/day for moderately susceptible organisms

Intramuscular:

Safety and efficacy of imipenem-cilastatin IM in pediatric patients below the age of 12 years have not been established.

Usual Pediatric Dose for Pneumonia with Cystic Fibrosis:

13 years or older, normal renal function: Up to 90 mg/kg/day IV in divided doses (based on imipenem content)

Maximum dose: 4 g/day

What other drugs will affect ImiNat C (imipenem and cilastatin)?

Before using ImiNat C (imipenem and cilastatin), tell your doctor if you are using any of the following drugs:

ganciclovir (Cytovene);

probenecid (Benemid);

a penicillin antibiotic such as amoxicillin (Amoxil), ampicillin (Omnipen, Principen), carbenicillin (Geocillin), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), or penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids, and others); or

a cephalosporin antibiotic such as cefaclor (Ceclor), cefuroxime (Ceftin), cefadroxil (Duricef), cephalexin (Keflex), and others.

Talk to your doctor and pharmacist before use ImiNat C (imipenem and cilastatin) if you are use any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

Your pharmacist has information about ImiNat C (imipenem and cilastatin) written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

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Erlocip - Tarceva (Erlotinib) ecp123456 $900.00	Geftinat - Iressa (Gefitinib) GNT1234567 $299.00	Bandrone - Boniva (Ibandronate) bdn12345 $75.00	Bandrone - Boniva (Ibandronate) bdn123456 $16.00
Arsenide - Trisenox (Arsenic Trioxide) Product 19 $15.00	Endace - Megace (Megestrol Acetate) End123456 $10.00	Alphalan - Alkeran (Melphalan) AL7891236 $100.00	Bortenat - Velcade (Bortezomib) BN123456 $375.00
Cantret - Hexalen (Altretamine) CT1234567 $141.00	Clokeran - Leukeran (Chlorambucil) CR1234567 $49.00	Docenat - Taxotere (Docetaxel) DNT1234567 $330.00	Fulvenat - Faslodex (Fulvestrant) Fnt1234567 $480.00

	LenaLid - (Lenalidomide) $180.00
	Bosentas - Tracleer (Bosentan) $36.00
	Bortenat - Velcade (Bortezomib) $375.00
	Xtane - Aromasin (Exemestane) $39.00
	Geftinat - Iressa (Gefitinib) $299.00

Iminat C - Primaxin (imipenem/cilastatin)

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